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Enzymes: EC Nomenclature - 3rd Level
Substrate Specificity

The list was taken from KEGG: Kyoto Encyclopedia of Genes and Genomes on Sept. 25th. 1998. CAUTION: All links connect to the data base of KEEG.

[ 1st Level | 2nd Level | 4th Level ]


EC (Enzyme Commission) numbers assigned by IUPAC-IUBMB




1. Oxidoreductases

  1.1  Acting on the CH-OH group of donors

    1.1.1  With NAD+ or NADP+ as acceptor
    1.1.2  With a cytochrome as acceptor
    1.1.3  With oxygen as acceptor
    1.1.4  With a disulfide as acceptor
    1.1.5  With a quinone or similar compound as acceptor
    1.1.99  With other acceptors
  
1.2  Acting on the aldehyde or oxo group of donors

    1.2.1  With NAD+ or NADP+ as acceptor
    1.2.2  With a cytochrome as acceptor
    1.2.3  With oxygen as acceptor
    1.2.4  With a disulfide as acceptor
    1.2.7  With an iron-sulfur protein as acceptor
    1.2.99  With other acceptors
  
1.3  Acting on the CH-CH group of donors

    1.3.1  With NAD+ or NADP+ as acceptor
    1.3.2  With a cytochrome as acceptor
    1.3.3  With oxygen as acceptor
    1.3.5  With a quinone or related compound as acceptor
    1.3.7  With an iron-sulfur protein as acceptor
    1.3.99  With other acceptors
  
1.4  Acting on the CH-NH2 group of donors

    1.4.1  With NAD+ or NADP+ as acceptor
    1.4.2  With a cytochrome as acceptor
    1.4.3  With oxygen as acceptor
    1.4.4  With a disulfide as acceptor
    1.4.7  With an iron-sulfur protein as acceptor
    1.4.99  With other acceptors
  
1.5  Acting on the CH-NH group of donors

    1.5.1  With NAD+ or NADP+ as acceptor
    1.5.3  With oxygen as acceptor
    1.5.4  With a disulfide as acceptor
    1.5.5  With a quinone or similar compound as acceptor
    1.5.99  With other acceptors
  
1.6  Acting on NADH or NADPH

    1.6.1  With NAD+ or NADP+ as acceptor
    1.6.2  With a heme protein as acceptor
    1.6.4  With disulfide as acceptor
    1.6.5  With quinone or related compound as acceptor
    1.6.6  With a nitrogenous group as acceptor
    1.6.7  Acting on NADH or NADPH
    1.6.8  With a flavin as acceptor
    1.6.99  With other acceptors
  
1.7  Acting on other nitrogenous compounds as donors

    1.7.2  With a cytochrome as acceptor
    1.7.3  With oxygen as acceptor
    1.7.7  With an iron-sulfur protein as acceptor
    1.7.99  With other acceptors
  
1.8  Acting on a sulfur group of donors

    1.8.1  With NAD+ or NADP+ as acceptor
    1.8.2  With a cytochrome as acceptor
    1.8.3  With a oxygen as acceptor
    1.8.4  With a disulfide as acceptor
    1.8.5  With a quinone or similar compound as acceptor
    1.8.6  Acting on a sulfur group of donors
    1.8.7  With an iron-sulfur protein as acceptor
    1.8.99  With other acceptors
  
1.9  Acting on heme group of donors

    1.9.3  With oxygen as acceptor
    1.9.6  With a nitrogenous group as acceptor
    1.9.99  With other acceptors
  
1.10  Acting on diphenols and related substances as donors

    1.10.1  With NAD+ or NADP+ as acceptor
    1.10.2  With a cytochrome as acceptor
    1.10.3  With oxygen as acceptor
    1.10.99  With other acceptors
  
1.11  Acting on a peroxide as acceptor

    1.11.1  Acting on a peroxide as acceptor
  
1.12  Acting on hydrogen as donor

    1.12.1  With NAD+ or NADP+ as acceptor
    1.12.2  With a cytochrome as acceptor
    1.12.7  Acting on hydrogen as donor
    1.12.99  With other acceptors
  
1.13  Acting on single donors with incorporation of molecular oxygen
        (oxygenases)

    1.13.11  With incorporation of two atoms of oxygen
    1.13.12  With incorporation of one atom of oxygen (internal monooxygenases
             or internal mixed function oxidases)
    1.13.99  Miscellaneous
  
1.14  Acting on paired donors with incorporation of molecular oxygen

    1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom
             each of oxygen into both donors
    1.14.12  With NADH or NADPH as one donor, and incorporation of two atoms of 
             oxygen into one donor
    1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of
             oxygen
    1.14.14  With reduced flavin or flavoprotein as one donor, and
             incorporation of one atom of oxygen
    1.14.15  With a reduced iron-sulfur protein as one donor, and incorporation 
             of one atom of oxygen
    1.14.16  With reduced pteridine as one donor, and incorporation of one atom 
             of oxygen
    1.14.17  With ascorbate as one donor, and incorporation of one atom of
             oxygen
    1.14.18  With another compound as one donor, and incorporation of one atom
             of oxygen
    1.14.99  Miscellaneous
  
1.15  Acting on superoxide radicals as acceptor

    1.15.1  Acting on superoxide radicals as acceptor
  
1.16  Oxidizing metal ions

    1.16.1  With NAD+ or NADP+ as acceptor
    1.16.3  With oxygen as acceptor
  
1.17  Acting on -CH2- groups

    1.17.1  With NAD+ or NADP+ as acceptor
    1.17.3  With oxygen as acceptor
    1.17.4  With a disulfide as acceptor
    1.17.99  With other acceptors
  
1.18  Acting on reduced ferredoxin as donor

    1.18.1  With NAD+ or NADP+ as acceptor
    1.18.3  Acting on reduced ferredoxin as donor
    1.18.6  With dinitrogen as acceptor
    1.18.99  With H+ as acceptor
  
1.19  Acting on reduced flavodoxin as donor

    1.19.6  With dinitrogen as acceptor
  
1.97  Other oxidoreductases

    1.97.1  Other oxidoreductases


2. Transferases
  
2.1  Transferring one-carbon groups

    2.1.1  Methyltransferases
    2.1.2  Hydroxymethyl-, formyl- and related transferases
    2.1.3  Carboxyl- and carbamoyltransferases
    2.1.4  Amidinotransferases
  
2.2  Transferring aldehyde or ketone residues

    2.2.1  Transferring aldehyde or ketone residues
  
2.3  Acyltransferases

    2.3.1  Acyltransferases
    2.3.2  Aminoacyltransferases
  
2.4  Glycosyltransferases

    2.4.1  Hexosyltransferases
    2.4.2  Pentosyltransferases
    2.4.99  Transferring other glycosyl groups
  
2.5  Transferring alkyl or aryl groups, other than methyl groups

    2.5.1  Transferring alkyl or aryl groups, other than methyl groups
  
2.6  Transferring nitrogenous groups

    2.6.1  Transaminases
    2.6.2  Transferring nitrogenous groups
    2.6.3  Oximinotransferases
    2.6.99  Transferring other nitrogenous groups
  
2.7  Transferring phosphorus-containing groups

    2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.2  Phosphotransferases with a carboxyl group as acceptor
    2.7.3  Phosphotransferases with a nitrogenous group as acceptor
    2.7.4  Phosphotransferases with a phosphate group as acceptor
    2.7.5  Transferring phosphorus-containing groups
    2.7.6  Diphosphotransferases
    2.7.7  Nucleotidyltransferases
    2.7.8  Transferases for other substituted phosphate groups
    2.7.9  Phosphotransferases with paired acceptors
  
2.8  Transferring sulfur-containing groups

    2.8.1  Sulfurtransferases
    2.8.2  Sulfotransferases
    2.8.3  CoA-transferases
  
2.9  Transferring other groups

    2.9.1  Seleniumtransferases


3. Hydrolases
  
3.1  Acting on ester bonds

    3.1.1  Carboxylic ester hydrolases
    3.1.2  Thiolester hydrolases
    3.1.3  Phosphoric monoester hydrolases
    3.1.4  Phosphoric diester hydrolases
    3.1.5  Triphosphoric monoester hydrolases
    3.1.6  Sulfuric ester hydrolases
    3.1.7  Diphosphoric monoester hydrolases
    3.1.8  Phosphoric triester hydrolases
    3.1.11  Exodeoxyribonucleases producing 5'-phosphomonoesters
    3.1.13  Exoribonucleases producing 5'-phosphomonoesters
    3.1.14  Exoribonucleases producing other than 5'-phosphomonoesters
    3.1.15  Exonucleases active with either ribo- or deoxyribonucleic acids and 
            producing 5'-phosphomonoesters
    3.1.16  Exonucleases active with either ribo- or deoxyribonucleic acids and 
            producing other than 5'-phosphomonoesters
    3.1.21  Endodeoxyribonucleases producing 5'-phosphomonoesters
    3.1.22  Endodeoxyribonucleases producing other than 5'-phosphomonoesters
    3.1.25  Site-specific endodeoxyribonucleases specific for altered bases
    3.1.26  Endoribonucleases producing 5'-phosphomonoesters
    3.1.27  Endoribonucleases producing other than 5'-phosphomonoesters
    3.1.30  Endonucleases active with either ribo- or deoxyribonucleic acids
            and producing 5'-phosphomonoesters
    3.1.31  Endonucleases active with either ribo- or deoxyribonucleic acids
            and producing other than 5'-phosphomonoesters
  
3.2  Glycosidases

    3.2.1  Hydrolysing O-glycosyl compounds
    3.2.2  Hydrolysing N-glycosyl compounds
    3.2.3  Hydrolysing S-glycosyl compounds
  
3.3  Acting on ether bonds

    3.3.1  Thioether hydrolases
    3.3.2  Ether hydrolases
  
3.4  Acting on peptide bonds (peptidases)

    3.4.11  Aminopeptidases
    3.4.13  Dipeptidases
    3.4.14  Dipeptidyl-peptidases and tripeptidyl-peptidases
    3.4.15  Peptidyl-dipeptidases
    3.4.16  Serine-type carboxypeptidases
    3.4.17  Metallocarboxypeptidases
    3.4.18  Cysteine-type carboxypeptidases
    3.4.19  Omega peptidases
    3.4.21  Serine endopeptidases
    3.4.22  Cysteine endopeptidases
    3.4.23  Aspartic endopeptidases
    3.4.24  Metalloendopeptidases
    3.4.99  Endopeptidases of unknown catalytic mechanism
  
3.5  Acting on carbon-nitrogen bonds, other than peptide bonds

    3.5.1  In linear amides
    3.5.2  In cyclic amides
    3.5.3  In linear amidines
    3.5.4  In cyclic amidines
    3.5.5  In nitriles
    3.5.99  In other compounds
  
3.6  Acting on acid anhydrides

    3.6.1  In phosphorus-containing anhydrides
    3.6.2  In sulfonyl-containing anhydrides
  
3.7  Acting on carbon-carbon bonds

    3.7.1  In ketonic substances
  
3.8  Acting on halide bonds

    3.8.1  In C-halide compounds
    3.8.2  Acting on halide bonds
  
3.9  Acting on phosphorus-nitrogen bonds

    3.9.1  Acting on phosphorus-nitrogen bonds
  
3.10  Acting on sulfur-nitrogen bonds

    3.10.1  Acting on sulfur-nitrogen bonds
  
3.11  Acting on carbon-phosphorus bonds

    3.11.1  Acting on carbon-phosphorus bonds
  
3.12  Acting on sulfur-sulfur bonds

    3.12.1  Acting on sulfur-sulfur bonds


4. Lyases
  
4.1  Carbon-carbon lyases

    4.1.1  Carboxy-lyases
    4.1.2  Aldehyde-lyases
    4.1.3  Oxo-acid-lyases
    4.1.99  Other carbon-carbon lyases
  
4.2  Carbon-oxygen lyases

    4.2.1  Hydro-lyases
    4.2.2  Acting on polysaccharides
    4.2.99  Other carbon-oxygen lyases
  
4.3  Carbon-nitrogen lyases

    4.3.1  Ammonia-lyases
    4.3.2  Amidine-lyases
    4.3.3  Amine-lyases
    4.3.99  Other Carbon-nitrogen lyases
  
4.4  Carbon-sulfur lyases

    4.4.1  Carbon-sulfur lyases
  
4.5  Carbon-halide lyases

    4.5.1  Carbon-halide lyases
  
4.6  Phosphorus-oxygen lyases

    4.6.1  Phosphorus-oxygen lyases
  
4.99  Other lyases

    4.99.1  Other lyases


5. Isomerases
  
5.1  Racemases and epimerases
    5.1.1  Acting on amino acids and derivatives
    5.1.2  Acting on hydroxy acids and derivatives
    5.1.3  Acting on carbohydrates and derivatives
    5.1.99  Acting on other compounds
  
5.2  cis-trans-Isomerases

    5.2.1  cis-trans-Isomerases
  
5.3  Intramolecular oxidoreductases

    5.3.1  Interconverting aldoses and ketoses
    5.3.2  Interconverting keto- and enol-groups
    5.3.3  Transposing C=C bonds
    5.3.4  Transposing S-S bonds
    5.3.99  Other intramolecular oxidoreductases
  
5.4  Intramolecular transferases (mutases)

    5.4.1  Transferring acyl groups
    5.4.2  Phosphotransferases (phosphomutases)
    5.4.3  Transferring amino groups
    5.4.99  Transferring other groups
  
5.5  Intramolecular lyases

    5.5.1  These catalyse reactions in which a group can be regarded as
           eliminated from one part of a molecule, leaving a double bond, while 
           remaining covalently attached to the molecule.
  
5.99  Other isomerases

    5.99.1  Other isomerases


6. Ligases
  
6.1  Forming carbon-oxygen bonds

    6.1.1  Ligases forming aminoacyl-tRNA and related compounds
  
6.2  Forming carbon-sulfur bonds

    6.2.1  Acid--thiol ligases
  
6.3  Forming carbon-nitrogen bonds

    6.3.1  Acid--ammonia (or amine) ligases (amide synthases)
    6.3.2  Acid--amino-acid ligases (peptide synthases)
    6.3.3  Cyclo-ligases
    6.3.4  Other carbon--nitrogen ligases
    6.3.5  Carbon--nitrogen ligases with glutamine as amido-N-donor
  
6.4  Forming carbon-carbon bonds

    6.4.1  Forming carbon-carbon bonds
  
6.5  Forming phosphoric ester bonds

    6.5.1  Forming phosphoric ester bonds






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