LON-CAPA Glycolysis Title & Selection Pane

Original URL: http://www.bio.cmu.edu/Courses/BiochemMols/Glycolysis/GlycolysisMain.htm

Images of Glycolysis Intermediates

Net reaction:
Glucose + 2P_i + 2ADP + 2NAD⁺ 2 pyruvate + 2ATP + 2NADH + 2H⁺ + 2H₂O

As written, the net reaction corresponds to steps 1-10 of glycolysis. The NADH produced is always recycled to NAD⁺ either by oxidative phosphorylation (with O₂) or by a fermentation pathway (without O₂).

**Energetics of Glycolysis**
Reaction Step	G°' (kcal/mol)
1. Hexokinase.	-4.0
2. Phosphoglucose isomerase.	+0.4
3. Phosphofructokinase.	-3.4
4. Aldolase.	+5.7
5. Triose phosphate isomerase.	+1.8
6. Glyceraldehyde 3-phosphate dehydrogenase.	+1.5
7. Phosphoglycerate kinase.	-4.5
8. Phosphoglyceromutase.	+1.1
9. Enolase.	+0.4
10. Pyruvate kinase.	-7.5
Fates for Pyruvate.
F1. Lactate dehydrogenase.	-6.0
F2. Pyruvate decarboxylase.	?
F2. Alcohol dehydrogenase.	?

from Stryer 2nd Ed. Table 12-2.