|
Magazine and Book Covers
Jean-Yves Sgro, Ph.D. | |||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| covers | size | legend | reference | ||||||||||||||||||||||||||||
cover size: | original art(reduced)
legend: Largest and smallest complete viral particles solved by X-Ray
crystallography. Both structures are reprented here to scale.
| The larger structure is simian virus 40 (PDB entry 1SVA, Stehle et. al. 1996), a Polyomavirus from the Papovaviridae family. The non-enveloped icosahedral particles, ~45 nm in diameter contains the circular dsDNA genome. 72 pentameric capsomers are arrange on a T=7d icosahedral lattice, 12 strict pentamers at the icosahedral vertices have only 5 neighbouring capsomers while the other and 60 pentameric capsomers are arranged in hexamers. View is along an icosahedral 2-fold axis of symmetry. The small structure is that of satellite tobacco necrosis virus (PDB entry 2STV, Unge et. al. 1980). The non-enveloped icosahedral particles, ~17 nm in diameter contains the linear ssRNA genome. 60 proteins are arranges on a T=1 icosahedral lattice. View is along an icosahedral 5-fold axis of symmetry. T.STEHLE,S.J.GAMBLIN,Y.YAN,S.C.HARRISON The structure of simian virus 40 refined at 3.1 A resolution STRUCTURE (LONDON) 4, 165 1996 T.UNGE,L.LILJAS,B.STRANDBERG,I.VAARA,K.K.KANNAN, K.FRIDBORG,C.E.NORDMAN,P.J.LENTZ *JUNIOR Satellite tobaco necrosis virus structure at 4.0 A resolution NATURE 285,373 1980
Archives of Virology
| All 1999 volumes. ISSN 0304-8608 Springer-Verlag Wien
| 
cover size: | 100% 50% original art(reduced)
legend: Coxscakievirus B3 image is a computer representation
derived fromx-ray coordinates (Mucklebauer et al. Structure 3:653,
1995). The PDB ENTRY for the virus is 1COV. The GRASP protein
molecular surface is radially depth-cued to visually highlight surface
features. The canyon is clearly evident. Note that the canyons are not
continuous around the 5-fold icosahedral axes. (Courtesy of Dr.
Jean-Yves Sgro, University of Wisconsin-Madison;
sgro@rhino.bocklabs.wisc.edu).
| Photomicrographs of 0.6 micron thick hemotoxylin and eosin stained sections of heart (above) and pancreas (below) taken from a C3H/HeJ male mouse, 10 days post-inoculation with the cardiovirulent wild-type strain of CVB3, CVB3/DO. Note significant and widespread regions of necrosis and calcification in heart section typical of results induced by infection with a cardiovirulent CVB3. Pancreas has sustained severe damage to acinar cells. Original magnification x100.
The Coxsackie B Viruses
| S. Tracy, N.M. Chapman and B.W.J. Mahy (Eds) Springer 1997 ISSN 0070-217X ISBN 3-540-62390-6 Library of Congress Catalog Card Number 15-12910
| 
cover size: | 100% 50% original art(reduced)
legend: Computer-generated image of poliovirus type 1 Mahoney
strain derived from X-ray coordinates (PDB entry 2PLV, Hogle et
al.) showing a virion oriented along one of twelve icosahedral
50fold symmetry axes. Image generated by J.-Y. Sgro with the program
GRASP on Silicon Graphics. There are three articles about poliovirus
in this issue: M.-M. Georgescu et al. (pages 1819-1828),
B. Rombaut and J.P. M. Jore (pages 1829-1832) and F. J. M. Kuppeveld
et al. (pages 1833-1840).
|
Image represents poliovirus type 1 Mahoney (X-ray data Hogle et al., 1985,
Science 229: 1358) seen along one icosahedral 5-fold axis. Down in the
depression around the 5-fold axis the small yellow sticks represent a visible
portion of the "pocket factor". In most rhinoviruses this pocket entry
would be blocked by the C-terminal end of the VP3 protein "hanging" above
the pore entrance.
Journal of General Virology
| Volume 78 Part 8 August 1997
| 
cover size: | 100% 50% original art(reduced)
No legend. | Image represents halved virion particles of Theiler's virus BeAn (green) and DA (orange) strains, showns side by side for comparison, created with Grasp on Silicon Graphics from PDB published coordinates (PDB entries 1TME (DA) and 1TMF (BeAn)). Image created by JY Sgro
Journal of General Virology
| Off-Print promotional cover 1997
| 
cover size: | 100% 50% original art(reduced) Computer graphics of the
three-dimensional structure of bean pod mottle virus. The surface of
virions has been radially depth-cued to enhance depiction of surface
topography. Virions on the left appear in various orientations;
prominent structures protrudeat axes of 5-fold symmetry (yellow); deep
depressions occur at axes of 2-fold symmetry; and small surface ridges
are visible at axes of 3-fold symmetry. The virion at the right has
been sliced through is center to reveal interior features. Capsid
protein atoms are delineated as blue spheres to show the capsid
thickness (<10 Å at 2-fold axes, > 40 Å at 5-fold
axes). About 20% of the virion RNA was detected; it appears as trefoils
(pink) at axes of 3-fold symmetry. In the foreground an edge of a
virion appeats at close range. The structure of this virus was solved
in the laboratory of J.E. Johnson, then at Purdue University
[Chen et al., Science 245:154-159 (1989)]. The illustration
was created on a Silicon Graphics Workstation, using the program
GRASP as developped by Anthony Nicholls of Columbia University.
The image was composed and produced by Jean-Yves Sgro of the
Institute for Molecular Virology, University of Wisconsin, 1525
Linden Drive, Madison, Wisconsin, 53706-1596 USA.
|
Archives of Virology
| All 1996 volumes. ISSN 0304-8608 Springer-Verlag Wien
| 
cover size: | 100% 50% original art(reduced)
Artistic rendering of a Mengo virion releasing its single stranded
RNA genome after infecting a cell.
Four kinds of viral coat proteins assemble following icosahedral
symmetry o form a shell around the genome. The icosahedral
5-fold axis of symmetry is easily recognized at the center of the
pentamers, star shaped raised surfaces. See "Using Viral Genes
to Fight Disease," p. 1050.
| Image created by JY Sgro
BIOTECHNOLOGY
| volume 13 October 1995 Number 10 ISSN 0733-222X Nature Publishing Co., owned by Nature America, Inc., a subsidiary of Macmillan Magazines of London.
| 
cover size: | 100% 50%
original art
Computer graphics representation of the virion of
human rhinovirus 14 along the icosahedral 3-fold axis
of symmetry, highlighting the topographic details
of the surface. Lighter colored structures are situated
further away from the virion center, showing
that the 5-fold axis region is the most prominent
feature. The "canyon" is clearly seen as a dark blue
depression around the 5-fold axis and is the binding site
for the cellular receptor ICAM-1. A depression is visible
at the icosahedral 2-fold axis of symmetry
(equidistant between two 5-fold vertices), but has no known
role.
Antibody binding sites determined by escape mutations are shown
in magenta and clearly appear in more exposed (white or light
blue) areas on "domes" and "ridges", suggesting that the dark
and blue areas are not within the reach of antibodies.
| Image created by JY Sgro
Medical Virology
| David O. White Frank J. Fenner Academic Press, Inc. ISBN 0-12-746642-8 1994
| 
cover size: | 100% 50%
original art
No legend.
| Image created by JY Sgro from VSurf Data (VSurfProgram from Michael Rossamnn) and visualized with FRODO on an Evans & Sutherland PS390 series workstation.
NIAID
| Report of the Task Force on Microbiology and Infectious Diseases U.S. Department of Health and Human Services Public Health Service National Institute of Health 1992 |
