Morph of reovirus virion to ISVP
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MPEG version
Quicktime version (1052K)
Summary
This movie of mammalian reovirus (created on a
Macintosh computer) animates the transition from virion to ISVP, the step
at which the virus particle loses a major portion of its outer shell.
The sigma-3 protein is lost by proteolytic degradation (in red), which
somehow allows the sigma-1 protein at the 5-fold axes or vertices (in
yellow) to protrude outward. The mechanism behind this major change in
conformation of sigma-1 is not known.
A morph is a combination of a cross-dissolve and the movement of pixels
in order to simulate a smooth transition between the start and end
images. This type of special effect is popular in movies and on TV (e.g.
a man turning into a wolf or panther).
The start and end images are courtesy of Kelly Dryden and Tim Baker,
Structural Biology Group at Purdue.
The data displayed were derived from computer image reconstruction of
cryo-electron micrographs.
Created July 1993.
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© 1994 Stephan Spencer. Institute for Molecular Virology/
sspencer@netconcepts.com
