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	Introduction to KEGG

Documents

• From sequence to function: an introduction to the KEGG project
• Biological knowledge base KEGG for post-genome analysis (in Japanese)

Slide Show

• Part 1: Is genome a blueprint of life? - A philosophical background of KEGG [pdf]
• Part 2: Data representation and abstraction in KEGG (available soon)
• Part 3: Functional prediction and reconstruction with KEGG (available soon)

On-line Manuals

• How to use pathway maps
• How to use hierarchical texts
• How to use java applets for genome maps

Additional Documents

• Release Notes
• How to obtain a local copy of KEGG
• URLs for making DBGET/LinkDB/KEGG queries

References on KEGG

1. Kanehisa, M.; Toward pathway engineering: a new database of genetic and molecular pathways. Science & Technology Japan, No. 59, pp. 34-38 (1996). [pdf]
2. Kanehisa, M. and Goto, S.; A systematic analysis of gene functions by the metabolic pathway database. In "Theoretical and Computational Methods in Genome Research" (Suhai, S., ed.), pp. 41-55, Plenum (1996).
3. Ogata, H., Bono, H., Fujibuchi, W., Goto, S., and Kanehisa, M.; Analysis of binary relations and hierarchies of enzymes in the metabolic pathways. Genome Informatics 7, 128-136 (1996). [GIW96014] [pdf]
4. Goto, S., Bono, H., Ogata, H., Fujibuchi, W., Nishioka, T., Sato, K., and Kanehisa, M.; Organizing and computing metabolic pathway data in terms of binary relations. Proc. Pacific Symposium on Biocomputing '97, pp. 175-186 (1996). [9390290] [pdf]
5. Kanehisa, M.; A database for post-genome analysis. Trends Genet. 13, 375-376 (1997). [9287494]

References on DBGET/LinkDB

1. Akiyama, Y., Goto, S., Uchiyama, I., and Kanehisa, M.; WebDBGET: an integrated database retrieval system which provides hyper-links among related entries. MIMBD'95: Second Meeting on the Interconnection of Molecular Biology Databases (1995). [pdf]
2. Goto, S., Akiyama, Y., and Kanehisa, M.; LinkDB: a database of cross links between molecular biology databases. MIMBD'95: Second Meeting on the Interconnection of Molecular Biology Databases (1995). [pdf]
3. Kanehisa, M.; Linking databases and organisms: GenomeNet resources in Japan. Trends Biochem Sci. 22, 442-444 (1997). [9397687]
4. Fujibuchi, W., Goto, S., Migimatsu, H., Uchiyama, I., Ogiwara, A., Akiyama, Y., and Kanehisa, M.; DBGET/LinkDB: an Integrated Database Retrieval System. Proc. Pacific Symposium on Biocomputing '98, in press (1997). [pdf]

Project Team

• Project Leader: Minoru Kanehisa
• Database Team: Susumu Goto, Hiroyuki Ogata, Hiroko Ishida, Sanae Asanuma, Noriko Man, Kana Matsumoto, Toshi Nakatani, Yasuko Okada
• Programming Team: Kazushige Sato, Wataru Fujibuchi, Toyoko Katsurada, Tomomi Kamiya, Mayuko Egoshi, Yoshiko Kimura, Masayuki Nakamura
• Curators: Takaaki Nishioka (metabolism), Kentaro Tomii (membrane transport), Hidemasa Bono, Atshuhiro Oka (signal transduction), Toshiaki Katayama (cell cycle), Masahiro Hattori (cell death), Yoshinobu Igarashi (cell-cell communication), Shuichi Kawashima (development), Park Keun-joon (nuclear transport)
• Collaborators: Evgeni Selkov, Ross Overbeek

Acknowledgments

The KEGG project is supported by the grant-in-aid for scientific research on the priority area "Genome Science" from the Ministry of Education, Science, Sports and Culture of Japan. An additional support for system development is given by the Human Genome Center of the University of Tokyo. The computational resources are given by the Supercomputer Laboratory of the Institute for Chemical Research, Kyoto University.

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