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Computer Visualizations of Viruses - Part 2

Rhinovirus

Rhinovirus 14, as solved by cryo-electron microscopy and image reconsruction courtesy of Tim Baker. Purdue University



Rhinovirus 14, color coded by protein, as solved by X-ray crystallography



Molecular surface of Rhinovirus 14, radially depth cued, as solved by X-ray crystallography

View along the 2-fold axis
More views along the 2-fold axis, 3-fold axis, 5-fold axis *
180 degree rotation (1.6MB Quicktime movie) *


Rhinovirus shown on 20/20 on abc TV. (quicktime and animated Gifs).



Rhinovirus 14, radially depth cued with antigenic sites highlighted, as solved by X-ray crystallography



Rhinovirus 14 complexed with neutralizing antibodies, as solved by cryo-electron microscopy and image reconstruction courtesy of Tim Baker. Purdue University



Rhinovirus 14 complexed with the ICAM-1 receptor, as solved by cryo-electron microscopy and image reconstruction courtesy of Tim Baker. Purdue University



Rhinovirus 16 with view of the interior, as solved by X-ray crystallography



Ross River Virus

Electron density isosurface of Ross River Virus, radially depth cued, as solved by cryo-electron microscopy and image reconstruction. (Structure solved by Tim Baker of Purdue University.)

Views along the 2-fold axis, 3-fold axis, 5-fold axis *
180 degree rotation (1.5MB Quicktime movie) *

Southern Bean Mosaic Virus

Molecular surface of Southern Bean Mosaic Virus, radially depth cued, as solved by X-ray crystallography

View along the 2-fold axis
More views along the 2-fold axis, 3-fold axis, 5-fold axis *
180 degree rotation (1.6MB Quicktime Movie) *


Molecular surface of Southern Bean Mosaic Virus, radially depth cued, as solved by X-ray crystallography



Close up view of the molecular surface of Southern Bean Mosaic Virus, radially depth cued, as solved by X-ray crystallography



Close up view of the molecular surface of Southern Bean Mosaic Virus, radially depth cued in blue, as solved by X-ray crystallography


Simian Virus 40

Molecular surface of Simian Virus, radially depth cued, as solved by X-ray crystallography


Satellite Tobacco Necrosis Virus

Molecular surface of Satellite Tobacco Necrosis Virus, radially depth cued, as solved by X-ray crystallography

Views along the 2-fold axis, 3-fold axis, 5-fold axis *
180 degree rotation (1.3 MB Quicktime movie) *


Theiler's Murine Encephalomyelitis Virus

Molecular surface of Theiler's Murine Encelphalomyelitis Virus, radially depth cued, as solved by X-ray crystallography

Views along the 2-fold axis, 3-fold axis, 5-fold axis *
180 degree rotation (1.4 MB Quicktime movie) *


Tobacco Mosaic Virus

Molecular surface of Tobacco Mosaic Virus, radially depth cued, as solved by X-ray crystallography

Views along the helical axis, down the helical axis *
180 degree rotation (1.1 MB Quicktime movie) *

Tomato Bushy Stunt Virus

Molecular surface of Tomato Bushy Stunt Virus, radially depth cued, as solved by X-ray crystallography

View along the 2-fold axis
More views along the 2-fold axis, 3-fold axis, 5-fold axis *
180 degree rotation (1.6MB Quicktime Movie) *


Turnip Yellow Mosaic Virus

Molecular surface of Turnip Yellow Mosaic Virus, radially depth cued, as solved by X-ray crystallography


Simulations

Simulation of a virus binding to a host cell receptor



Morph animation of mammalian reovirus virion to ISVP transition



Morph animation of mammalian reovirus ISVP to core transition at a vertex



Mammalian reovirus ISVP with simulated flexible spikes



References

  1. Spencer SM, Sgro JY, Dryden KA, Baker TS, Nibert ML
    IRIS explorer software for radial-depth cueing reovirus particles and other macromolecular structures determined by cryoelectron microscopy and image reconstruction.
    J Struct Biol 1997 Oct; 120(1):11-21

  2. Nicholls A, Sharp KA, Honig B
    Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons.
    Proteins 1991;11(4):281-296



* Visualizations designated with an asterisk (*) are reproduced with permission from the Encyclopedia of Virology Plus CD-ROM. (Edited by Robert G. Webster and Allan Granoff. © 1995 Academic Press Ltd All Rights Reserved.

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Content: ©1994-1999 Stephan Spencer & Jean-Yves Sgro
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Last Modified March 20, 1999